Measures of Autozygosity in Decline: Globalization, Urbanization, and Its Implications for Medical Genetics
نویسندگان
چکیده
منابع مشابه
Measures of Autozygosity in Decline: Globalization, Urbanization, and Its Implications for Medical Genetics
This research investigates the influence of demographic factors on human genetic sub-structure. In our discovery cohort, we show significant demographic trends for decreasing autozygosity associated with population variation in chronological age. Autozygosity, the genomic signature of consanguinity, is identifiable on a genome-wide level as extended tracts of homozygosity. We identified an aver...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2009
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1000415